But Ramos insists Pique supporting the controversial independence referendum has not strained their relationship further.
Defending In Numbers is a new Deezer Originals football podcast, created by Squawka.
That stance saw him whistled at by supporters during the global break, but Spain managed to orchestrate wins over Albania and Israel as they sealed a place at the 2018 World Cup.
'It hurts the national team, ' Ramos said.
"Pique's behaviour has always been exemplary despite what others may think".
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President Donald Trump responded to the attack, tweeting: "In NYC, looks like another attack by a very sick and deranged person". Twenty-nine-year-old Sayfullo Habibullaevic Saipov used a Home Depot truck to mow down pedestrians in a bike lane.
Given their part in rivals teams challenging for La Liga glory, Ramos and Pique have not always enjoyed the best relationship - with El Clasicos often involving fights and arguments between compatriots.
The Spain global recently revealed his frustration at being continuously forced to prove himself at the Bernabeu despite spending two seasons at a club of Juventus' stature.
'If you compare it with the old relationship we had, I tell you that today we get along quite well. Before there was nearly no relationship.
'When you are growing and maturing you leave aside things that you previously gave importance to and do not have now.
Morata has made an impact since joining Chelsea in the summer and Ramos conceded that the striker was always going to have a better chance of making it big at another club and not Real Madrid as he was never going to receive the minutes he wanted at the Bernabeu.
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