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Principale » One vaccine injection could carry many doses

One vaccine injection could carry many doses

15 Septembre 2017

The containers can be filled with a drug or vaccine and are created to break down at various points in time to release the contained fluid. The team found that single injection of these particles induced a strong immune response that was similar to that of two regular injections with double dose.

MIT engineers have invented a new 3-D fabrication method that can generate a novel type of drug-carrying particle that could allow multiple doses of a drug or vaccine to be delivered over an extended time period with just one injection.

The cups are filled by an automated system before being sealed. The particles are made of a biocompatible, FDA-approved polymer that can be created to degrade at specific times, spilling out the contents of the "cup". Large arrays of about 2,000 molds are fit onto a glass slide, and these molds are used to shape the PLGA cups (cubes with edge lengths of a few hundred microns) and lids.

Ana Jaklenec, a research scientist at MIT's Koch Institute for Integrative Cancer Research, said: "Each layer is first fabricated on its own, and then they're assembled together".

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It involves a new 3D fabrication method. One particular application for this technology is in vaccines for developing countries where parents might not be able to bring small children to a remote clinic numerous times for a sequence of injections and precisely-scheduled boosters.

The molecular weight of the PLGA polymer and the structure of the polymer molecules' "backbone" determine how fast the particles will degrade after injection. The researchers then used imaging techniques to see when the substance was released and found it last around nice days, 20 days or 41 days, depending on which polymer they used.

The days of traipsing to and from the GP for a series of vaccinations could be over, scientists have predicted, after they developed a new technique to deliver several doses in one injection. "That might be the difference between not getting vaccinated and receiving all of your vaccines in one shot", McHugh said. They have also designed capsules that degrade hundreds of days after injection, although they stress that there is a challenge here in developing vaccines that will remain stable inside the capsules for that long.

One vaccine injection could carry many doses