For women, not sharing the same level of sexual interest with a partner, and not sharing the same sexual likes and dislikes, had a significant impact on their likelihood to lose interest in sex.
Conducted by researchers at Southampton University, factors such as lack of emotional closeness, communication issues and poor health were cited as reasons for having a lower sex drive in both men and women.
A similar association was seen between women whose general interests differed from those of their partners and lack of sex drive.
More turn-offs for women were having children under five and having given birth in the a year ago, the study found.
Overall, roughly a third of women (34%) said they lacked interest in sex, compared with 15% of men, the study published in the journal BMJ Open found.
In the National Survey of Sexual Attitudes and Lifestyles in Britain, those who found it "always easy to talk about sex" with their partner were less likely to say they lacked interest. "But talking is often the best thing you can do to improve your sex life".
The researchers found interest in sex gradually declined with age among women, with 25 percent of 11 to 24-year-olds saying they were uninterested in sex, a rate that rose to 39 percent among 55 to 64-year-olds.
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"It highlights the needs to asses and -if necessary - treat sexual interest problems in a holistic and relationship, as well as gender-specific, way". Among men, however, interest barely changes with age, briefly dipping between the ages of 35 and 44 before rising again in middle age and retirement.
Even among 65 to 74-year-olds, just 14 percent of men said they were uninterested in sex.
However, those whose partner had had sexual difficulties, and those who were less happy in their relationship, were more likely to say they had lost interest in sex at some stage, the researchers said.
Women who lived with a partner were also more at risk of having a low sex drive, and were twice as likely to report a lack of interest in sex than their male counterparts.
The researchers said that when it comes to sexual desire, problems should be addressed by looking at the whole person or persons involved, rather than just taking medications.
Both men and women said they were put off sex by past experiences of violent sex, poor mental and physical health, and recent sexually transmitted infections.
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