She will play either Scotland's Kirsty Gilmour or China's He Bingjiao.
The 24-year-old from Guntur had come into the match with twin victories over Son Wan in June at the Indonesia Open Super Series Premier and Australia Open Super Series but it counted for little as the Korean dished out a near-perfect game to outclass the Indian in a 49-minute clash.
Sindhu defeated her opponent 21-14, 21-9 in the quarter-final clash of the tournament.
Srikanth, however, eased into the quarterfinals with yet another straight-game win over Denmark's Anders Antonsen in men's singles.
The world No. 4 Indian will next take on another Chinese - world No. 10 Chen Yufei, who saw off former world champion Ratchanok Intanon of Thailand.
India will be assured of a medal if any of the three shuttlers left in the singles draw win their quarter-final matches.
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Indian badminton star PV Sindhu on Friday reached the semi-finals of the BWF World Championship by beating China's Sun Yu.
Five-time victor Lin Dan also defeated Wong Wing Ki Vincent to reach the semi-finals. Sindhu's aggressive game, which included cross-court half smashes and down-the-line winners, put Yu under pressure and she looked out of sorts on most occasions.
While Sindhu was in the groove on Friday, the same can not be said about Srikanth, who went down 21-14, 21-18 in 48 minutes against Son Wan Ho to make a surprise exit.
In many ways it had been the ideal match, just competitive enough to give her a work-out without any major alarms, albeit there was a reminder of the need to maintain concentration at this level when, from 18-9 ahead during the first game, she lost seven of nine points before wrapping things up with a neat sliced cross court overhead. Of late, a rivalry between the two has grown since Sindhu has taken over the baton over her senior compatriot.
Son took the momentum into the second game and easily took a massive 16-5 lead. However, Son Wan grabbed the match point when Srikanth rushed into a shot and hit the net. "Gopi sir and I didn't really get to speak about the match after it was over".
Srikanth now is a win away from confirming his maiden World Championships medal as he will be in action in the last-eight match in the morning session in Glasgow on Friday, August 25.
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