"Alexis will not be available for example, so I can not go into the game with too many uncertainties", Wenger said.
That Wenger is not going into the new campaign with the fans still at his throat owes much to Arsenal's strong finish to last season.
New recruit Harry Maguire is expected to be assigned to Lacazette and he is aiming to stop the French forward who has scored 91 goals in the French Ligue 1 over the past four seasons.
Arsenal took 45 points at home last season but finished fifth in the table.
It looked bad for quite a while but Arsenal did come good and we broke the opening day run.
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"Whether he does or not, I expect Arsenal to win, but only just".
City have spent more than £200million on a squad revamp following last season's underwhelming campaign.
"We have to try and win most of games that we compete in but we know the rollercoaster that the Premier League can be as well".
The Algeria global has stated his wish to leave the 2015/16 Premier League champions, but Wenger insists Arsenal do not need the winger and were never looking to land his signature. Laurent Koscielny is banned, while Per Mertesacker, Mesut Ozil, Jack Wilshere and Aaron Ramsey are fitness doubts.
"We've got our first game this Friday coming and we can't wait to get started".
Both Ozil and Alexis Sanchez are in the final 12 months of their respective contracts, and troubled negotiations over new terms have led to both being linked with moves away from the Emirates Stadium, per Ashton. "I'm happy with the effort the club did and I'm happy they managed to do 75 percent of the work before the Premier League starts". Making things worse are injuries to Danny Drinkwater and Vicente Iborra, the latter a new signing from Sevilla.
Mourinho added: "We got a central defender that can play in many other positions, which is important".
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