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HIV-prevention ring a hit with teen girls

26 Juillet 2017

"The trend toward lower adherence to Truvada for PrEP as study visits became less frequent parallels what was observed in in a study of PrEP in adolescent gay and bisexual boys, suggesting that monthly study visits may support greater adherence to oral PrEP among adolescents over time", said Linda-Gail Bekker, deputy director of the Desmond Tutu HIV Center at the University of Cape Town.

Studies have shown that it provides a 92%-99% reduction in HIV risk for the individuals who take the pills every day as directed. Almost 1,000 are infected every day in sub-Saharan Africa.

A monthly vaginal ring containing the antiretroviral dapivirine has demonstrated efficacy in girls younger than 18 years, according to phase 2a study results presented at the IAS Conference on HIV Science. Earlier this month, the International Partnership for Microbicide announced that the application for the ring was under review by the European Medicines Agency for use in adult women.

Results of ASPIRE and The Ring Study, which were reported in February 2016, found the ring reduced women's risk of acquiring HIV by about 30 percent overall (by 27 percent in ASPIRE and by 31 percent in The Ring Study).

This new study is the first time that the ring is tested in a younger population, disproportionately affected by HIV in Africa.

"The study has demonstrated that the ring is safe in USA teens, and now we need data on the safety and acceptability of the ring in African adolescent girls", said Sharon Hillier, the principal investigator of the study and professor at the University of Pittsburgh School of Medicine. "HIV doesn't distinguish between a 16-year-old and an 18-year-old".

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The post Vaginal ring preventing HIV to be tested in Africa appeared first on Vanguard News. "Young women of all ages deserve to be protected".

The six-month United States trial gave the ring to 96 sexually active girls aged 15 to 17, who had not used it before.

The research recruited 96 girls aged 15 to 17 from six sites across the USA, 73 of which were in the dapivirine ring group and 23 were assigned to use the placebo ring.

There were some concerns before the trial that the girls' partners would not like the feel of the ring, but it reportedly enhanced pleasure.

"The study has demonstrated that the ring is safe in USA teens, and now we need data on the safety and acceptability of the ring in African adolescent girls". Questions asked of participants three months into the study and after six months indicated the ring was highly acceptable, with 95 percent saying the ring was easy to use and 74 percent indicating they were not aware of the ring during daily activities.

In the group wearing the dapivirine ring, 87% of plasma samples had detectable levels of drug suggestive of the ring being used the previous day and 95% of the rings returned after use had drug levels that suggested consistent use during the previous month. About 42 percent never removed the ring except when replacing it with a new one.

HIV-prevention ring a hit with teen girls