Two other teenage girls, also thought to have taken the substance, were taken to Torbay District Hospital as a precaution.
Officers were informed by paramedics that the unconscious girl was located in Bakers Park in Newton Abbot in the early hours of Saturday morning.
She was taken to Torbay District Hospital at around 4.50am but died while being treated, police said.
A police spokesman said: 'Her next of kin have been informed and police are supporting the family.
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Devon and Cornwall Police said: "Police now believe that both girls had taken a new psychoactive substance, more commonly referred to as "legal highs", and had suffered adverse reaction".
A police cordon has been put in place around Bakers Park in Newton Abbot, where the youngsters had been.
Police in Kingsbridge, 20 miles to the south of...
Last year Totnes teenager Nathan Wood died after after taking the psychoactive drug N-Bomb.
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