Houston amassed 14 hits and five walks with Evan Gattis and Carlos Correa going deep, driving in two and scoring two times while George Springer homered twice, knocked in five and scored four times.
Houston's Carlos Correa extended the longest active hitting streak in the majors to a career-high 15 with his 18th homer in the first inning.
The support eased Charlie Morton's (6-3) return to action.
Troy Tulowitzki and Ezequiel Carrera hit solo homers for Toronto (40-46). The right-hander, sidelined since May 24 with a right lat strain, gave Houston one-run ball over six innings, surrendering four hits to tie his season low.
Sanchez had been out since May 20.
Bolsa Mexicana abre con pérdida 0.06%
El principal indicador accionario, el S&P/BMV IPC , subió 259.23 enteros respecto al nivel previo para ubicarse en 50 mil 300.81 unidades.
Toronto's Jeff Beliveau took over in the eighth from Mike Bolsinger, who allowed six hits and four runs while striking out seven in 5 1/3 innings of relief.
Pearce went 1-for-3 with a RBI and a walk on Thursday out of the seven-hole, but he'll bat fifth tonight opposite Astros left-hander Charlie Morton. In a corresponding move, the team optioned Dominic Leone to Triple-A Buffalo in order to make room on the 25-man roster. Stroman was lifted from his previous start Monday at Yankee Stadium because of a blister on his pitching hand.
Sanchez's ERA on the season ballooned from 3.33 to 4.85.
Blue Jays: Stroman (8-5, 3.42) has picked up the loss in three of his past four starts, after going nearly two months without one before that.
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