The Boston bullpen walked Jorge Bonifacio, Lorenzo Cain, and Eric Hosmer to start the bottom of the eighth inning before Perez crushed the game-winning home run to left field. It was a bad matchup - the Red Sox stuck with Scott because lefty Mike Moustakas was on deck - and Perez capitalized with his 15th homer of this year and first ever grand slam; he had been a.268/.261/.366 hitter in 41 at-bats with the bases loaded.
Joakim Soria (3-2) pitched the 8th inning and got the win.
The Red Sox have a day off on Thursday before opening up a weekend series against the Los Angeles Angels on Friday.
Boston is 4-1 in Sale's last 5 starts and 1-6 in their last 7 road games against a left-handed starter while the under is 5-1-2 in their last 8 games overall. Still, he has allowed 35 earned runs in 62.2 innings.
Cabrera actually gave the two bats to Royals catcher Drew Butera, who then lent one to Perez on Wednesday in Kansas City.
"I was thinking about it two pitches before", Perez said.
The Red Sox banged out a dozen hits, led by Chris Young going 3-for-4 with a run-producing double and scoring a run. Rick Porcello will get the ball for Boston and will be opposed by Alex Meyer.
The fortunes of Jason Hammel and the Kansas City Royals have taken similar turns this season. Kelvin Herrera also threw a scoreless 9th inning to rack up his 16th save of the year. The leadoff homer was Boston's first hit, and the 100th of Benintendi's career.
Trump says he's 'very supportive' of new Senate health care bill
Like the House version , the Senate bill eliminates the " individual mandate " that people buy insurance or face fines. A vote on the bill is planned for the end of next week before lawmakers leave Washington for the July 4 recess.
Boston's Christian Vazquez slides home to score on a sacrifice fly by Mookie Betts during the fifth inning of a 6-4 loss to the host Kansas City Royals on Wednesday afternoon.
Royals rookie left-hander Matt Strahm (2-4) failed to make it out of the fourth inning, facing four batters in that frame and all scored, as the Red Sox seized a 5-1 advantage.
"He gave us everything we could have hoped for tonight", Red Sox manager John Farrell said. Hosmer finally dinged him in the third with an estimated 446-foot shot to center, a line drive that cleared the seats and landed in the fountains.
The bullpen meltdown spoiled a good outing from starter Drew Pomeranz who allowing two runs in 6 1/3 innings, while scattering six hits.
Perez had a ideal day at the plate, with two other hits and a walk.
"Given the workload that (Kimbrel) went through, what he was feeling coming out of those three particular appearances, that wasn't something that we looked to entertain", Farrell said. Xander Bogaerts and Sandy Leon each collected two hits and two RBIs.
The Royals won the series opener on Monday, 4-2, but the Red Sox answered with an 8-3 win on Tuesday night.
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