But while there is still plenty at stake for Palace, United can not move from sixth position and the Red Devils' boss Jose Mourinho has said he intends to play several youngsters, with his focus on the Europa League final against Ajax in Stockholm on Wednesday.
Man United face Crystal Palace just three days before the most important fixture of their season and there's no doubt Mourinho will be making plenty of changes to his side as he won't want to risk his best players.
"We will play our 56th game next Wednesday and if you look at the age of the players we have, then it is a really young team who have also played a lot of games", said Bosz. (Demetri) Mitchell. (Josh) Harrop. "I think a team shouldn't play two..."
Asked if he had submitted a request for the game to be moved, Mourinho replied: "I don't lose time".
"They are a Champions League team, they come from the Champions League, I always disagree with it", the United manager said. "And I hope you don't kill me when you see my team". I never saw. It's just a lost battle, we have to accept the way it is.
Now, he will rest everybody this week and the next time they play, the last time they played together as a team would have been against Celta Vigo. I hope the fans support the team, forgive naivety and lack of confidence. Tells ( Wilfried) Zaha to go slow, leaves (Christian) Benteke at home.
"Obviously there is a big difference of quality, strength, experience between them and good players, experienced players like Crystal Palace have".
Bayern Munich induct retiring Lahm into Hall of Fame
Bayern Munich manager Carlo Ancelotti has hit back at claims that he has not given young players a chance. Alonso made his mark at three of the world's biggest clubs - Liverpool, Real Madrid and Bayern.
Axel Tuanzebe retains his place after impressing at White Hart Lane while Paul Pogba is missing from the squad altogether as he attends the funeral of his father.
The result at St Mary's was United's 15th draw of a frustrating league season and means they are guaranteed to register their lowest number of wins in a campaign since the 1990-91 season. We finished fifth (in last season's Premier League), we went to the Europa League.
"Everyone goes", Mourinho said of his travelling party.
Southampton manager Claude Puel refused to discuss his future at the club, which is the subject of speculation.
But United were already guaranteed to finish sixth, while Southampton, who have not scored in four successive top-flight home games for the first time, remain eighth.
"Fosu-Mensah plays Sunday [against Crystal Palace] and if the reaction is good and he plays without problems, he is a new option for us for the final".
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