Despite her loss, Le Pen's advancement to the runoff for the first time marked a breakthrough for the 48-year-old and underscored a growing acceptance of her anti-immigration, France-first nationalism.
Newly-elected French President Emmanuel Macron has brought relief to a Europe fearing another Brexit-style populist upheaval or Trump-inspired protest vote.
Trump had backed neither Macron nor his far-right rival Marine Le Pen ahead of the vote's second round.
The possibility of a Le Pen presidency had unnerved some after polls had failed to accurately read the popular sentiment that led to Britain's vote past year to leave the European Union and the election of President Donald Trump.
Far-right leader Marine Le Pen lost her bid to become France's first female head of state but she is unbowed, making plans for a major makeover of her party and her next electoral battle: June's parliamentary elections.
The En Marche! party will now be called Republique en Marche, or Republic on the Move, party secretary-general Richard Ferrand said on Monday.
The French presidential race - which has been closely watched around the world - became the latest referendum in the West on globalization and its benefits and societal costs.
Earlier, thousands of French voters in the United Kingdom cast their ballots in the decisive presidential run-off.
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Hillary Clinton, who lost last year's election to Trump, tweeted, "Victory for Macron, for France, the European Union, & the world". The world of arts has been anti-Le Pen throughout the contentious campaign.
Theresa May was among European leaders to congratulate Mr Macron on his victory.
Whatever Le Pen's defeat means for populism's long-term future, Macron's victory can not disguise the fact that France remains a deeply-riven society on a number of issues and those divisions are not going to go away anytime soon. "We look forward to working with the new president and continuing our close cooperation with the French government", Spicer said according to the statement.
"A new page of our history has turned this evening, I want that page to be one of hope and refound trust, the renewal of our public life, will be at the base of what I do from the very first day of our presidency".
U.S. Treasury yields rose, with the benchmark yield at a five-week high in advance of the sale of $62 billion in bond supply at this week's quarterly refunding and following Macron's victory. He must garner a parliamentarian majority in order govern, while keeping the fresh image of new politics disconnected from the old system.
The final week of the race was marked by dramatic twists and turns.
That, and left-wing frustration at Macron's candidacy, triggered a sharp spike in abstentions and blank and spoiled ballots _ representing 36 percent of the electorate.
That election saw a dip in the abstention rate to 20.3 percent. Both the news media and public opinion suggested Macron was the clear victor. While she wished him success, she continued to criticize her opponent as an establishment candidate, saying the French people had voted for "continuity". The hacked documents did not appear to gain much traction and were not seen to have an effect on today's results.
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