Jose Mourinho has dipped further into the Manchester United academy and brought a youthful squad to Southampton.
The move casts further doubt over De Gea's future at United as Real Madrid prepare to make a bid in excess of £60million for the 26-year-old Spain worldwide.
United know they can not break into the top four on the strength of their final two Premier League games against Southampton and Crystal Palace, as they trail Liverpool by eight points with only six left up for grabs.
Keane's arrival may lead to Chris Smalling's departure with the England defender becoming increasingly disillusioned over Mourinho's comments.
Meanwhile, Michael Carrick is confident of extending his stay at United.
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And Mourinho revealed that the midfielder would be in France rather than St. Mary's to pay his respects.
I never, ever have had a situation like this and on top of that the accumulation of big injuries, not small, not the injuries that you say "ok, hamstring, two weeks". You know that in all of my career I was never out of European competitions in the group phases.
"We qualified by winning the FA Cup, and because only ourselves and Southampton went through into that first round we got a bigger share of the market pool, and also the performance of Southampton and Tottenham later on in the competition meant that we picked up a bigger share of that market pool and will do throughout the knockout stages". And it is not only the former UEFA Cup trophy that is on the line for the Premier League side. But like this I never have, I never have. In the domestic competitions cups, I won in Spain, in Italy, in Portugal so I normally have a lot of matches. It's all so hard. So this is a period in one week when I have to give one day off and now I give a day off to Valencia.
'Monday, Daley Blind one day off. Ander Herrera one day off. They have nothing to play for here, and you saw at White Hart Lane on Sunday what United looks like when they aren't fully engaged.
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