That means their only hope of Champions League qualification rests with beating Ajax in Stockholm on May 24 - and Mourinho has rotated players in Premier League matches in recent weeks as he has plotted his way through the Europa League.
Balancing the desire to win with resting players has been hard and Mourinho said it would have been worse it not for Oliver's decision to red card Ander Herrera sending off in the 1-0 FA Cup quarter-final defeat at Chelsea in March.
"When I have 14, 15 players, I can't do it". This is a period in one week I have to give a day off.
"But we fight for titles and probably other clubs finishing in the top four, probably they would like to be in our position to try and fight for the title".
The odds of it occurring are astronomical but with less than a week of the Premier League season remaining, Liverpool, Arsenal and Manchester City could finish dead level in the table.
"But like this, I never have".
Promise has been mixed with frustration during the Portuguese's first season in the Old Trafford hot-seat, with EFL Cup and Community Shield successes tempered by Premier Leagues struggles. In domestic cups, I won in Spain, Italy, Portugal, I normally have a lot of matches.
"This is insane. And I repeat the same - thank you Michael Oliver [for sending off Herrera] because we were out in the FA Cup".
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"If we go to the FA Cup semi-final it would be a complete disaster".
Mourinho said the number of games played and injuries suffered by his players this season was unprecedented in his time as a manager.
"For me, it's important that every time we have honesty with the club and the fans".
"Team spirit, empathy and the fantastic attitude that everybody has is not one more victory, one more point, one more defeat that is going to change something."
He has already revealed that Daley Blind will be rested for Wednesday's rearranged game at Southampton, with the versatile Dutch defender having started six of United's last seven matches.
Schweinsteiger said: "I had a talk with him and he had an opinion, maybe it was not made by himself".
"I think (it would be different) if we would have met in a different situation". "We have left him completely free to be back when he thinks he's ready".
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