A brace from Olivier Giroud 42′, 80′, sandwiched strikes from Mesut Özil 55′ and Alexis Sánchez 76′ while Peter Crouch scored for the home team.
They would want to finish in the top-half of the table but three league wins since January sees Arsenal as favourites to take advantage, especially given the visitors' upturn in form. He side are three points adrift with three games to play.
A curious and perhaps remarkable fact is that it was the first time Arsenal had taken the lead away to Stoke in a Premier League match; such has been their poor record here.
He was singled out for criticism by Arsenal fans during the 3-0 defeat at Crystal Palace last month and now the former Barcelona youngster, who has been linked with a return to Catalonia this summer, is likely to come into the team for a vital game at the bet365 Stadium.
Arsenal boss Arsene Wenger vowed his focus would remain on his side's push for Champions League football and not the protests against him after a 4-1 win at Stoke. We have 69 points, on Tuesday will look to make it 72.
The victory means Arsenal will move above Manchester United into fifth place and three points behind fourth-placed Manchester City.
"The first half was quite even but we were focused, determined, maintained the pace and in the second half we found space to create chances and finish the game off", said Wenger.
Bottas pleased with qualifying
Trailing Mercedes throughout Friday, Ferrari hit back with the top two times heading into qualifying. Bottas will start tomorrow's Spanish Grand Prix from P3 with the Ferrari of Raikkonen alongside him.
Consecutive 2-0 wins have given Arsenal the opportunity to pull just one point behind Liverpool tomorrow if they beat Stoke, with Jurgen Klopp's side then facing a hard battle against West Ham at the London Stadium on Sunday.
"We were okay and had a good shape in the first half, but in terms of what we wanted to do in attack, that didn't really happen for us".
The veteran French manager has never finished outside the Premier League's top four in a full season in charge, having joined Arsenal in September 1996. If the good form continues, the players stay healthy, and if Wenger can maintain his strong character, then Manchester City may be denied a top four finish.
Since their arrival in the Premier League in 2008, only Manchester City (14) have had more red cards in home league games than Stoke (13).
Wenger's men then sign off on the season with the FA Cup final against London rivals Chelsea.
"We need to be more potent, we are aware of that, and we would love to address that over the final two games".
"We just have to win our games".
- Chelsea not that far ahead, says Liverpool boss Klopp
- Oilers take command of series with another win in Anaheim
- Portuguese ballad wins Eurovision 2017
- China Calls for Further Cooperation with Spain
- China tests new missile near Korean peninsula
- Arsenal beat Southampton as they chase Champions League spot
- One big step to Champions League, says Liverpool's Emre Can
- Massive Cyberattack Affects Numerous Countries
- Trump Delivers His First Commencement Address As President At Liberty University
- Friday Flicks: King Arthur: Legend of the Sword & Norman